Riociguat for treatment of experimental right heart hypertrophy
نویسندگان
چکیده
منابع مشابه
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چکیده ندارد.
15 صفحه اولTonin in rat heart with experimental hypertrophy.
The present study was undertaken to determine tonin expression and activity in rat heart presenting isoproterenol-induced hypertrophy. Renin, angiotensin-converting enzyme (ACE), and angiotensinogen (AG) expression were also determined. Wistar rats were treated with isoproterenol for 7 days (5 mg x kg(-1) x day(-1) sc). For untreated animals, the levels of tonin-specific activity in the atrium ...
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متن کاملRiociguat for pulmonary arterial hypertension associated with congenital heart disease
OBJECTIVE The Pulmonary Arterial hyperTENsion sGC-stimulator Trial-1 (PATENT-1) was a randomised, double-blind, placebo-controlled phase III trial evaluating riociguat in patients with pulmonary arterial hypertension (PAH). PATENT-2 was an open-label long-term extension to PATENT-1. Here, we explore the efficacy and safety of riociguat in the subgroup of patients with persistent/recurrent PAH a...
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ژورنال
عنوان ژورنال: Journal of the Saudi Heart Association
سال: 2012
ISSN: 1016-7315
DOI: 10.1016/j.jsha.2012.06.210